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Engineering enzymes to help solve the planet’s plastic problem

To test their platform, they went on to develop a new enzyme, HotPETase, through the directed evolution of IsPETase. IsPETase is a recently discovered enzyme produced by the bacterium Ideonella sakaiensis, which can use PET as a carbon and energy source.  While IsPETase has the natural ability to degrade some semi-crystalline forms of PET, the …

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